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| Volume 6 Issue 2 Year 2011 | ||
Using wavelet-transform to detecting of origin of replication in human DNA
Scherbakov A., Porozov Yu. Saratov State Technical University, 410054, Saratov, st. Polytechnicheskaya, 77 Abstract. Origins of replication (ORI) prediction in human genome is very important for modern biology. The proposed approach for prediction ORI’s positions in human genome is based on finding of hidden dependencies in nucleotide sequences by the their wavelet spectra comparison. Parameters of the wavelet transform were selected on the basis of data about known ORI. Application of wavelet transform with the found parameters for the ORI prediction in sequences with unknown ORI location within random nucleotide sequences got good results. Results of the analysis of nucleotide sequences wavelet spectra can be used either alone as an indicator of ORI and as one of the factors in the different classifiers, such as the Bayesian classifier, Support Vector Machines and others. The paper listed the advantages and disadvantages of the proposed method and some possible ways to improve its effectiveness.
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Table of Contents
Original Article
Math. Biol. Bioinf. 2011;6(2):147-160 doi: 10.17537/2011.6.147 published in Russian Abstract (rus.) Abstract (eng.) Full text (rus., pdf) References Supplementary data
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