The Application of Model Reduction Methods to the Construction of the Composite Model of Apoptotic Pathways
Kutumova E.O., Zinovyev A.Y., Sharipov R.N., Kolpakov F.A.
Design Technological Institute of Digital Techniques, The Siberian Branch of The Russian Academy of Sciences, Novosibirsk 630090, Russia
Institute of Systems Biology, Ltd, Novosibirsk 630090, Russia
Curie Institute, Paris F-75248, France
Institute of Computational modelling, The Siberian Branch of The Russian Academy of Sciences, Krasnoyarsk 660036, Russia
Institute of Cytology and Genetics, The Siberian Branch of The Russian Academy of Sciences, Novosibirsk 630090, Russia
Abstract. We propose a new approach to composition of mathematical models of biological systems, based on their reduction. This approach has been tested on the example of two apoptosis models describing pro- and anti-apoptotic (activation of NF-κB) pathways of CD95.
Key words: mathematical modeling, model reduction, CD95-induced apoptosis, transcription factor NF-κB, BioUML