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Volume 11   Issue 2   Year 2016
Stoichiometric Modeling of Oxygen Transportation through the Surface of Isolated Perfused Rat Liver

Shadrin K.V., Pakhomova V.G., Rupenko A.P., Kryukova Ξ.V., Khlebopros R.G.

Krasnoyarsk Science Centre of the Siberian Branch of Russian Academy of Science
Krasnoyarsk State Medical University
Siberian Federal University
Russian Academy of Science Siberian Branch Institute of Biophysics

Abstract. Stoichiometric modeling allows analyzing the features of metabolism both the cell populations and the holistic isolated organs. In this paper, one of the stoichiometric modeling methods, Flux Balance Analysis, was used to investigate the mechanisms of oxygen transportation through the surface of the  isolated perfused  rat liver at various oxygenation conditions. It is shown that the oxygen intake through the surface of the isolated perfused liver is associated with energy consumption.
 
Key words: stoichiometric modeling, the oxygen transportation, perfusion, hypoxia.
Table of Contents Original Article
Math. Biol. Bioinf.
2016;11(2):263-277
doi: 10.17537/2016.11.263
published in Russian

Abstract (rus.)
Abstract (eng.)
Full text (rus., pdf)
References

 

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