A Modular Visual Model of Energy Metabolism in Human Skeletal Muscle
Kiselev I.N.1,2, Akberdin I.R.2,3,6, Vertyshev A.Yu.4, Popov D.V.5, Kolpakov F.A.1,2
1Institute of Computational Technologies SB RAS, Novosibirsk, Russian Federation
2BIOSOFT.RU, LLC, Novosibirsk, Russian Federation
3Novosibirsk State University, Novosibirsk, Russian Federation
4CJSC "Sites-Tsentr", Moscow, Russian Federation
5Institute of Biomedical Problems of the Russian Academy of Sciences, Moscow, Russia
6Federal Research Center Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia
Abstract. The paper presents a modification of a multi-compartmental mathematical model describing the dynamics of intracellular species concentrations and fluxes in human muscle at rest. A modular representation of a complex model is proposed, which provides the possibility of rapid expansion and modification of the model compartments to account for the complex organization of muscle cells and the limitations of the rate of diffusion of metabolites between intracellular compartments. To illustrate the work of the model, intracellular response in human skeletal muscle to acute aerobic two-legged cycle ergometer training was considered. The model in SBML format is available at http://wiki.biouml.org/index.php/Muscle_metabolism.
Key words: mathematical model, module modeling approach, skeletal muscle, physical exercise, metabolism, physiology, BioUML.