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| Volume 20 Issue 2 Year 2025 | ||
A Method for Evaluating the Feasibility of Chargaff's Second Rule. Testing the Rule on Bacterial Chromosomes
Panyukov V.V. Institute of Mathematical Problems of Biology RAS , Keldysh Institute of Applied Mathematics of Russian Academy of Sciences, Pushchino, Russia
Abstract. In 1979, Chargaff published a mathematical formulation of his second rule, which states that in each of the complementary strands of two stranded DNA, the amount of adenine is equal to the amount of thymine and the amount of guanine is equal to the amount of cytosine. This rule has now been tested on numerous groups of sequences belonging to various organisms and, with a small number of exceptions, has been confirmed in most cases, but the conclusions about the feasibility of the rule are qualitative rather than quantitative. To our knowledge, no large-scale tests of the rule on bacterial genomes have been carried out. In the proposed work, the rule is tested on 38830 non-degenerate bacterial sequences extracted from the NCBI GenBank 2023 repository. We perform a more complete statistical analysis of the feasibility of the rule in bacterial genomes than is customary in the literature. A new approach to assessing the validity of the rule is proposed.
Key words: Chargaff’s second parity rule, bacterial genomes, Vysochanskij–Petunin inequality
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Table of Contents
Original Article
Panyukov V.V. A Method for Evaluating the Feasibility of Chargaff's Second Rule. Testing the Rule on Bacterial Chromosomes. Ìàthematical biology and bioinformatics. 2025;20(2):494-508. doi: 10.17537/2025.20.494 (published in Russian) Abstract (rus.) Abstract (eng.) Full text (rus., pdf) References Translation into English Panyukov V.V. A Method for Evaluating the Feasibility of Chargaff's Second Rule. Testing the Rule on Bacterial Chromosomes. Ìàthematical biology and bioinformatics. 2025, 20(Suppl.):t63-t77. doi: 10.17537/2025.20.t63 Full text (eng., pdf)
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