Tools and Algorithms for Nanopore Sequencing Data Analysis in Genomics, Metagenomics, and Epigenomics
Eremin A.A., Sergeev A.V., Zvereva M.E., Khrenova M.G.
Lomonosov Moscow State University, Moscow, Russia
Abstract. Nanopore sequencing is a promising technology for reading long fragments of DNA and RNA. This paper reviews modern algorithms and software tools used for the analysis of nanopore sequencing data in genomics, metagenomics, and epigenomics. The article describes the algorithms behind the most widely used software tools, highlighting their strengths and limitations. The presented review is useful for researchers working with nanopore sequencing data, as well as for developers of new methods for processing bioinformatics data.
Key words: nanopore sequencing, de novo genome assembly, genomics, epigenomics, metagenomics, long reads