Identification of Gene Markers for Aggressive Forms of Low-Grade Glioma Using TCGA Expression Data
Ivanisenko N.V., Gubanova N.V., Kolchanov N.A., Ivanisenko V.A.
Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia
Novosibirsk State University, Novosibirsk, Russia
Abstract. Low-grade glioma is a group of tumors of central nervous system. Unlike other malignant subtypes such as glioblastoma multiforme, low-grade gliomas have a lower mortality. However, after initial treatment in about 40% of low-grade gliomas new tumor events are observed. In this study identification of new genes responsible for the aggressive phenotype of tumors was carried out using RNA-seq data from the The Cancer Genome Atlas (TCGA) database. It was found that 85 genes with affected expression levels were associated with new tumors after initial treatment of low-grade glioma.
Key words: low-grade glioma, RNA-seq, new tumor event, TCGA.