Phenotypic Variability of Bacterial Cell Cycle: Mathematical Model
Likhoshvai V.A., Khlebodarova T.M.
Institute of Cytology and Genetics, Siberian Branch, Russian Academy of Sciences, Novosibirsk, Russia
Novosibirsk State University, Novosibirsk, Russia
Abstract. The results of the study of mechanisms of different cell phenotypes occurrence in a genetically homogenous population using the bacterial cell cycle model are presented. It was shown that phenotypic variability represents an internal, immanent property of bacteria. The basis of this phenomenon is universal non-linear properties of the conjugated transcription-translation system, that controls all cellular processes. Phenotypic variability occurs in a simple, deterministic, self-reproducing system under the uniform transmission of the structural components to the daughter cells during division and in the absence of any special control mechanisms of molecular-genetic processes and enzymatic reactions.
Key words: bacteria, cell cycle, modelling, phenotypic variability.